- "Oh shit!! Here comes the cavalry."
- ―Alex Mercer about Strike teams.[src]

A strike team attacking Alex.
Strike Teams are fast-moving, powerful squads of soldiers, specifically designed to strike fast and hard. Soldiers and vehicles will periodically call for strike teams when engaging Alex Mercer in combat, and flying viral detectors will summon them immediately upon detecting him. A red icon will appear above the responsible enemy, and killing them before they complete the call will cancel the request. Destroying a military base will prevent Strike Teams from deploying until it is rebuilt, and it can be useful to do this prior to starting a difficult mission.
During the early stages of the quarantine, each Strike Team consists of one to two transport Helicopters, which will drop off a squad of marines. As the story progresses, Strike Teams will consist of up to four Gunships and flying viral detectors. The Strike Team can be either destroyed or evaded by disguising outside of their view; in both cases the player will receive an EP bonus and the military can call in a replacement.
In Prototype 2, Strike Teams function differently. Soldiers will call for a Strike Team as soon as they spot Heller while he is in Free Roam (Strike Teams will not arrive during missions), and it will automatically arrive after a set period of time. As there is no opportunity to prevent this by killing the radioman, the player can only prevent the Strike Team's arrival by defeating or disengaging from the enemy before it is deployed. How powerful the Strike Team is depends on which zone the player is, as opposed to which act of the game they are in. Yellow Zone strikes will consist of a single transport helicopter, Green Zone strikes of a gunship and a transport, and Red Zone strikes of two gunships and a transport. The player will only be attacked by one Strike Team per alert.
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