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Lairs are infected underground areas that contain entities/creatures Heller can consume to upgrade his powers and abilities. Each chamber has a unique upgrade to a certain power. They function as an Infected "breeding chamber". A lair can be noticed by light leaking from the ground and a couple of infected civilians walking around. Heller can lift up the debris in the area exposing the lair, and jump down into it. 
Inside, the lairs are crawling with enemies, some of which he can consume to gain Evolution points. Infected Pustules continuously spawn hordes of infected until they are taken out. Note that Blackwatch troops or Evolved may also be present.