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"So many minds at work. All talking. All dying."
―Alex describing the Hive Mind.[src]

Alex trying to gain the Hive mind.

The Hive Mind is telepathic link between the Infected, and the mechanism that allows the Runners to organize the infected.

Alex consumed infected minds to link himself to the Hive Mind so he could track down the Leader Hunter that had kidnapped Dana. After consuming the Leader Hunter responsible for taking Dana, Alex's connection to the Hive Minds showed him where Dana was being held.

Elizabeth Greene was the focus of the Hive Mind - the leader, until Alex used the Parasite to kill her. It appears that the Supreme Hunter is another focus of the hive mind as he was able to call the Infected to his aid when he first fought Alex.